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hemorrhage in the second and third decades of life. The inclusion of milder sickle syndromes, and subtle neurologic abnormalities related to a low hematocrit, emphasizes the need for closer patient follow-up and studies of the risk/benefit ratio of chronic prophylactic transfusion therapy or alternative treatments (Adams RJ et al. N Engl I Med 1998;339:5-11).doi:10.15844/pedneurbriefs-13-3-11 fatcat:uc334at5e5cenfiylbkjvzxiv4