Study on Clinical Manifestations of SLE and its Anti-Nuclear Antibodies Profile

P. Murali Madhav
2017 Annals of International medical and Dental Research  
SLE clinical manifestations and course are highly variable, ranging from indolent to fulminant by the production of antibodies to cell nucleus components and also towards cytoplasmic antigens. Autoantibodies helps to diagnose SLE appropriately. The present study is undertaken to know the varied clinical features of SLE prevalence and also to know the ANA profile in relation to SLE. Methods: All the patients were examined and advised to undergo an ANA profile diagnostic checkup by ELISA. ANA
more » ... p by ELISA. ANA autoantibodies tested were anti dsDNA, anti-Nucleosome, anti-Histone, anti nRNP (Ribonucleoprotein), anti Sm (Smith), anti La, anti RO-52. ANA profile data was collected and also clinical features of SLE was noted. Collected data was analyzed and represented in the form of percentages. Results: Among these most predominant feature was oral lesions, was 87.5% and joint pains, was 82.8% followed by Hair loss (78.1%), fever (71.8%). Anti dsDNA antibodies were reported in 78.1% which were the most commonest autoantibodies. Among other autoantibodies, anti-histone anti-nucleosome were reported predominantly with percentages 56.2% and 29.6% respectively. Conclusion: Need a good diagnostic methods for confirmation of SLE and to start accurate treatment and also to assess the prognosis of SLE. Among various diagnostic methods analyzing ANA profile helps to confirm the diagnosis with good accuracy.
doi:10.21276/aimdr.2017.3.3.me1 fatcat:j77visfio5ggjl6cr7v65spvua