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Exploiting prior knowledge about biological macromolecules in cryo-EM structure determination
[article]
2020
bioRxiv
pre-print
Three-dimensional reconstruction of the electron scattering potential of biological macromolecules from electron cryo-microscopy (cryo-EM) projection images is an ill-posed problem. The most popular cryo-EM software solutions to date rely on a regularisation approach that is based on the prior assumption that the scattering potential varies smoothly over three-dimensional space. Although this approach has been hugely successful in recent years, the amount of prior knowledge it exploits compares
doi:10.1101/2020.03.25.007914
fatcat:5pglr3zwpbchbbeiazhu4veqcu