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Exploring CYP2B6 activity by measuring the presence ofnevirapine hydroxy metabolites in plasma
2016
Turkish Journal of Medical Sciences
Background/aim: Nevirapine is a reverse-transcriptase inhibitor widely used in combination therapy to treat HIV infection. Nevirapine is extensively metabolized in the liver and CYP2B6 is mainly responsible for oxidation of 3-hydroxynevirapine (3-OH NVP). This study aims to explore CYP2B6 activity by measuring 2-hydroxynevirapine (2-OH NVP) and 3-OH NVP in plasma and to identify factors associated with nevirapine pharmacokinetic parameters. Materials and methods: A total of 112 patients were
doi:10.3906/sag-1503-116
pmid:28081342
fatcat:7tlu7hx4bfbm5pc6767w3twohm