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Public and private human T cell clones respond differentially to HCMV antigen when boosted by CD3 co-potentiation
Human cytomegalovirus (HCMV) induces long-lasting T cell immune responses that control but do not clear infection. Typical responses involve private T cell clones, expressing T cell antigen receptors (TCR) unique to a person, and also public T cell clones with identical TCRs active in different people. Here, we report the development of a pre-therapeutic immunostimulation modality against HCMV for human T cells, CD3 co-potentiation, and the clonal analysis of its effects in recall assays atdoi:10.1101/2020.07.08.193805 fatcat:epzwpkdrtndyvmpny3oe2tvloq