Isolation and characterization of a new cytotoxic polyketide–amino acid hybrid from Thermothelomyces thermophilus ATCC 42464

Yang-Le Gao, Ming-Liang Zhang, Xue Wang, Huai-Dong Zhang, Jian-Zhong Huang, Li Li
2019 Figshare  
Fungi are a rich source of novel anticancer compounds. Bioassay-guided isolation has led to the isolation of four polyketide-amino acid hybrid compounds with trans-fused decalin system from the fungus Thermothelomyces thermophilus ATCC 42464 (=Myceliophthora thermophila ATCC 42464): myceliothermophins A, B, E and F (1–4). The structure of the new compound (myceliothermophin F, compound 4) was clearly determined by a combination of nuclear magnetic resonance (NMR) analysis and high-resolution
more » ... high-resolution electrospray ionisation mass spectroscopy (HRESIMS). The new compound exhibited promising cytotoxicity against some cell lines derived from colorectal carcinoma, hepatic carcinoma and gastric carcinoma, indicating that compounds with trans-fused decalin system would be promising in the course of developing novel anticancer drugs.
doi:10.6084/m9.figshare.8898671.v1 fatcat:gvplvbpk6bbk5j6mixbcrvngla