OctreoSCAN Imaging in Somatostatin Receptor-positive Cell Tumour

Donka Vassileva, Sonia Sergieva
2013 Comptes Rendus de l'Academie Bulgare des Sciences / Proceedings of the Bulgarian Academy of Sciences  
Various tumours contain high numbers of somatostatin receptors, which enable the use of somatostatin receptor scintigraphy (SRS) for visualization of these tumours. The purpose of this study was to assess the value of SRS, serum β-2-microglobulin and the correlation between them for diagnosis and staging of patients with malignant lymphomas. Forty-five patients with malignant lymphomas were investigated (20 with non-Hodgkin's lymphomas and 25 with Hodgkin's Disease). Planar and SPECT images
more » ... nd SPECT images were performed 24 and 48 h after i.v. injection of 110-185 MBq 111 In labelled pentetreotide (OctreoSCAN) on the rotating gamma camera (Diacam, Siemens). SRS results were compared with the data of conventional methods (clinical examination, X-ray, CT, bone marrow biopsy). β-2-microglobulin levels were measured by radioimmunoassay using the Immunotech International Microtest. The SRS was true positive in 36 patients with malignant lymphomas. Ninety-two lesions were identified, 69 of them with nodal localization -neck, hilar, mediastinal, axillar and inguinal. 23 of all were with extranodal localization in the region of the lung, bones and stomach. Seven previously unknown
doi:10.7546/cr-2013-66-1-13101331-19 fatcat:uq6n6lertrb25pyrz6yqgp7zba