Original Article Delayed graft function in living-donor renal transplantation: a single-center experience with 1537 patients

Faruk Ozkul, Halil Erbis, Vural Yilmaz, Bunyamin Ozturk, Huseyin Kocak, Ibrahim Osmanoglu, Ayhan Dinckan
2016 Int J Clin Exp Med   unpublished
Objectives: To analyze the incidence, clinical characteristics and possible causes of delayed graft function (DGF) among a large number of living kidney transplant recipients at a single center. Patients and Methods: We analyzed the medical records of 1537 patients over 18 years of age who received a kidney transplant from a living donor between January 2003 and June 2014. The demographic characteristics of the patients, graft survivals, acute rejection rates and renal functions were compared
more » ... tween patients with and without DGF. Results: Longer dialysis time before transplantation (50.6 ± 53.1 vs. 31.4 ± 42.9 months; P<0.001) and lower donor GFR (48.2 ± 10.2 vs. 45.4 ± 13 months; P=0.014) were associated with a greater incidence of DGF in this series. The DGF cases showed a higher incidence of acute rejection episodes (19.9% vs. 4.8%), chronic graft dysfunction (10% vs. 1%), prolonged hospitalization (16.8 ± 6.7 days vs. 8.3 ± 5.6 days), and worse renal function after 1-year follow-up period compared with non-DGF patients. Conclusions: Longer dialysis time before transplantation and lower donor GFR were associated with a higher risk for DGF, with prolonged hospitalization time, worse graft prognosis and higher rates of acute rejection episodes and chronic graft dysfunction.
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