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Faculty of 1000 evaluation for Merkel cell polyomavirus and two previously unknown polyomaviruses are chronically shed from human skin
F1000 - Post-publication peer review of the biomedical literature
Mounting evidence supports the concept that Merkel cell polyomavirus (MCV) is a causal factor underlying most cases of a highly lethal form of skin cancer known as Merkel cell carcinoma. To explore the possibility that polyomaviruses commonly infect healthy human skin, we developed an improved rolling circle amplification (RCA) technique to isolate circular DNA viral genomes from skin swab specimens. Complete MCV genomes were recovered from 14/35 (40%) healthy adults, providing the firstdoi:10.3410/f.3636969.3352072 fatcat:3psjc7fv3jhpfp52np3sytgphy