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A Network Polypharmacology Approach to Drug Repurposing for Diffuse Intrinsic Pontine Glioma
[article]
2020
bioRxiv
pre-print
Despite five decades of clinical investigations, there is currently no effective treatment for children diagnosed with Diffuse Intrinsic Pontine Glioma (DIPG). We now understand that DIPGs share the same histone 3 mutation and fatal prognosis as other diffuse midline gliomas (DMGs), which led to the introduction of a new entity referred to as DMG, H3 K27M mutant. Indeed, therapeutics indicated for other brain neoplasms have proven ineffective for DIPGs. We posit that by using a
doi:10.1101/2020.06.14.150714
fatcat:vwknosbe3zduvmhgb7xielo3oe