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Synthesis of New [γ-(Aryl)pyridino]dibenzo-27,28-Diazacrownophanes Containing Two Pyridine Rings
2019
Macroheterocycles
In continuation of developing new cytotoxic compounds, six azacrownophanes containing both 2,4,6-triarylpyridine and 2,6-bis(phenoxymethyl)pyridine moieties were synthesized successfully by one-step domino-condensation of podand 2,6-bis [(2-acetophenyl)oxymethyl]pyridine, arylaldehydes and ammonium acetate according to the conditions of Hantzsch reactions. The compounds 5a-c were selected for cytotoxicity evaluations against human cell lines (HepG2, Lu1, RD,. Compound 5b showing the highest
doi:10.6060/mhc190231a
fatcat:ziaf3mfyivcerllaz6g5tyodei