Synthesis of New [γ-(Aryl)pyridino]dibenzo-27,28-Diazacrownophanes Containing Two Pyridine Rings

Le Tuan Anh, Nguyen T. T. Huyen, Pham T. T. Tam, Nguyen T. Dat, Truong Hong Hieu, Tran T. T. Van, Luong T. M. Hanh, Anatoly T. Soldatenkov, Ayalew T. Wodajo
2019 Macroheterocycles  
In continuation of developing new cytotoxic compounds, six azacrownophanes containing both 2,4,6-triarylpyridine and 2,6-bis(phenoxymethyl)pyridine moieties were synthesized successfully by one-step domino-condensation of podand 2,6-bis [(2-acetophenyl)oxymethyl]pyridine, arylaldehydes and ammonium acetate according to the conditions of Hantzsch reactions. The compounds 5a-c were selected for cytotoxicity evaluations against human cell lines (HepG2, Lu1, RD,. Compound 5b showing the highest
more » ... toxicity is interesting for the development of promising anticancer drugs.
doi:10.6060/mhc190231a fatcat:ziaf3mfyivcerllaz6g5tyodei