Changes in The Diversity of Human Skin Microbiota to Cosmetic Serum Containing Prebiotics: Results From A Randomized Controlled Trial
Background: Prebiotic treatment may rebalance the skin microbiota by regulating the growth of harmful and beneficial microorganisms. Methods: In this randomized, double-blind, placebo-controlled clinical trial (N = 60), we evaluated the effects of a cosmetic serum containing galacto-oligosaccharides (GOS) on the balance of the skin microbiota by measuring various skin parameters. Results: The skin water-holding capacity between the control (ND) and experimental (NF) groups was significantly
... s significantly different after 8 weeks of serum treatment (p < 0.05). Similarly, changes in transepidermal water loss (TEWL) and the erythema index in the ND and NF groups were significantly different (p < 0.05). Furthermore, the wrinkle depth and Staphylococcus aureus population decreased in the NF group compared with those in the ND group (p < 0.05). The mean form factor, Shannon index, and Pediococcus population were significantly increased in the post-NF group compared with those in the post-ND group (p < 0.05). Finally, in the ND group, water-holding capacity was positively correlated with Enhydrobacter, whereas Enterobacteriaceae was negatively correlated with TEWL in the NF group. Conclusions: These results suggest that GOS inhibit the growth of harmful skin microbes and increase the population of beneficial microbes.