Risk factors for epithelial ovarian cancer in the female population of Belgrade, Serbia: A case-control study

Tatjana Gazibara, Aleksandra Filipovic, Vesna Kesic, Darija Kisic-Tepavcevic, Tatjana Pekmezovic
2013 Vojnosanitetski Pregled  
Background/Aim. Ovarian cancer (OC) comprises 3% of all cancers, but it is the fifth most common cause of cancer death in women. The aim of this case-control study was to determine the risk factors for OC in the female population of Belgrade, Serbia. Methods. A total of 80 consecutive patients were enrolled in the study between 2006 and 2008 in two national referral centers for OC in Serbia. The control subjects were recruited during the regular gynecological check-ups in the Public Health
more » ... Public Health Center of the corresponding municipalities. All the study participants were interviewed during their visits to the above mentioned institutions by two physicians using the same questionnaire. In order to analyze the influence of specific exposure to the risk of the disease, we categorized variables according to the cut-off values. Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated separately for each variable using univariate conditional logistic regression analysis. Results. There were no statistically significant differences in educational level, years of schooling, occupational and employment status between patients with OC and women in the control group. Oral contraceptives use and other contraceptive methods (condoms, mechanical contraceptive devices) were highly statistically significantly more frequent among women in the control group (OR = 0.2, 95% CI 0.1-0.7, p = 0.005; OR = 0.1, 95% CI 0.01-0.5, p = 0.001, respectively). The patients with OC practiced sports for 6.3 ± 2.1 years, and controls for 11.8 ± 9.9 years. Sport and recreation activities were statistically significantly protective (OR = 0.2, p = 0.011; OR = 0.4, p = 0.019). Tea consumption on daily basis had a highly statistically significat protective effect (OR = 0.3, p = 0.001). Conclusions. Oral contraceptives use and physical activity were independent protective factors for OC in this study. Key words: ovarian neoplasms; risk factors; motor activity; contraceptive agents. Apstrakt Uvod/Cilj. Karcinom ovarijuma ini 3% od svih karicnoma, i zauzima 5. mesto me u naj eš im uzrocima smrti od karcinoma kod žena. Cilj ove studije bio je da se utvrde faktori rizika od nastanka epitelijalnog karcinoma ovarijuma u ženskoj populaciji Beograda. Metode. Studija je izvedena u periodu od 2006. do 2008. godine. Ukupno 80 bolesnica iz dva tercijarna centra u Beogradu sa dijagnozom epitelijalnog karcinoma ovarijuma uklju eno je u studijsku grupu. Kontrolnu grupu inile su žene koje su dolazile na redovne godišnje ginekološke preglede u domove zdravlja opština u kojima su živele. Podatke su prikupljala dva lekara putem upitnika. U cilju procene uticaja specifi ne izloženosti riziku od pojave bolesti, varijable su kategorisane prema grani nim (cut-off) vrednostima. Unakrsni odnos (odds ratio -OR) i 95% interval poverenja (95% IP) izra unavani su za svaku varijablu pojedina no koriš enjem univarijantne logisti ke regresije. Rezultati. Izme u grupe bolesnica i kontrole grupe nije postojala statisti ki zna ajna razlika u nivou obrazovanja, dužini školovanja, zanimanju i zaposlenosti. Oralni kontraceptivi i druge metode kontracepcije (prezervativi, mehani ka kontraceptivna sredstva) bili su statisti ki visokoznaajno eš e koriš eni me u ženama u kontrolnoj grupi nego kod bolesnica sa ovarijalnim karcinomom (OR = 0,2; 95% IP 0,1-0,7; p = 0,005 za oralne kontraceptive; OR = 0,1, 95% IP 0,01-0,5 p = 0,001 za druge metode kontracepcije). Ispitanice sa ovarijalnim karcinomom bavile su se sportom u proseku 6,3 ± 2,1 godine, dok je za one iz kontrolne grupe taj period u proseku iznosio 11,8 ± 9,9 godina. Sport i rekreacija imali su statisti ki zna ajan zaštitni efekat na nastanak ovog tumora (OR = 0,2, p = 0.011; OR = 0,4, p = 0,019, redom). Statisti ki visokozna ajan zaštitni efekat imala je dnevna konzumacija aja (OR = 0,3, p = 0,001). Zaklju ak. Upotreba oralnih kontraceptiva i fizi ka aktivnost bili su nezavisni zaštitni faktori od nastanka epitelijalnog karcinoma ovarijuma u našoj studiji. Klju ne re i: jajnik, neoplazme; faktori rizika; motorna aktivnost; kontrola ra anja, sredstva. Strana 1098 VOJNOSANITETSKI PREGLED Volumen 70, Broj 12 Gazibara T, et al.
doi:10.2298/vsp110629030g pmid:24450253 fatcat:gynvamac3bedddr3re7fu7cmlu