Flexible decision under ambiguous cues reverses neural signaling from occipitotemporal to prefrontal cortex [article]

Kaho Tsumura, Keita Kosugi, Ryuta Aoki, Masaki Takeda, Junichi Chikazoe, Kiyoshi Nakahara, Koji Jimura
2020 bioRxiv   pre-print
Flexible adaptation to changing environments is one of the representative executive control functions, and requires appropriate extraction of environmental information to achieve a behavioral goal. It still remains unclear however, how the behavioral flexibility is guided under situations where the relevant behavior is ambiguous. Using functional brain mapping of machine-learning decoders and directional functional connectivity, we show that brain-wide reversible neural signaling underpins
more » ... ling underpins behavioral flexibility in ambiguously changing environments. When relevant behavior is cued ambiguously during behavioral shifting, neural coding of the behavior is attenuated in distributed cortical regions, but top-down signals from the prefrontal cortex complements the coding. On the other hand, when shifting to the alternative behavior is cued more explicitly, modality-specialized occipitotemporal regions implement distinct neural coding about the relevant behavior, and bottom-up signals from the occipitotemporal region to the prefrontal cortex supplements the behavioral shift. These results suggest that our adaptation to an ever-changing world is orchestrated by the alternation of top-down and bottom-up signaling in the fronto-occipitotemporal circuit depending on the availability of environmental evidences.
doi:10.1101/2020.07.29.227736 fatcat:oavbladzhfaopnya7mhxz5q5rq