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Profiling Persistent Asthma Phenotypes in Adolescents: A Longitudinal Diagnostic Evaluation from the INSPIRERS Studies

Rita Amaral, Cristina Jácome, Rute Almeida, Ana Margarida Pereira, Magna Alves-Correia, Sandra Mendes, José Carlos Cidrais Rodrigues, Joana Carvalho, Luís Araújo, Alberto Costa, Armandina Silva, Maria Fernanda Teixeira (+33 others)
2021 International Journal of Environmental Research and Public Health  

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We aimed to identify persistent asthma phenotypes among adolescents and to evaluate longitudinally asthma-related outcomes across phenotypes. Adolescents (13–17 years) from the prospective, observational, and multicenter INSPIRERS studies, conducted in Portugal and Spain, were included (n = 162). Latent class analysis was applied to demographic, environmental, and clinical variables, collected at a baseline medical visit. Longitudinal differences in clinical variables were assessed at a 4-month
more » ... follow-up telephone contact (n = 128). Three classes/phenotypes of persistent asthma were identified. Adolescents in class 1 (n = 87) were highly symptomatic at baseline and presented the highest number of unscheduled healthcare visits per month and exacerbations per month, both at baseline and follow-up. Class 2 (n = 32) was characterized by female predominance, more frequent obesity, and uncontrolled upper/lower airways symptoms at baseline. At follow-up, there was a significant increase in the proportion of controlled lower airway symptoms (p < 0.001). Class 3 (n = 43) included mostly males with controlled lower airways symptoms; at follow-up, while keeping symptom control, there was a significant increase in exacerbations/month (p = 0.015). We have identified distinct phenotypes of persistent asthma in adolescents with different patterns in longitudinal asthma-related outcomes, supporting the importance of profiling asthma phenotypes in predicting disease outcomes that might inform targeted interventions and reduce future risk.
doi:10.3390/ijerph18031015 pmid:33498858 fatcat:26gkffmbejg2bjulop34eicrpm
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Rita Amaral, Cristina Jácome, Rute Almeida, Ana Margarida Pereira, Magna Alves-Correia, Sandra Mendes, José Carlos Cidrais Rodrigues, Joana Carvalho, Luís Araújo, Alberto Costa, Armandina Silva, Maria Fernanda Teixeira, Manuel Ferreira-Magalhães, Rodrigo Rodrigues Alves, Ana Sofia Moreira, Ricardo M. Fernandes, Rosário Ferreira, Paula Leiria Pinto, Nuno Neuparth, Diana Bordalo, Ana Todo Bom, Maria José Cálix, Tânia Ferreira, Joana Gomes, Carmen Vidal, Ana Mendes, Maria João Vasconcelos, Pedro Morais Silva, José Ferraz, Ana Morête, Claúdia Sofia Pinto, Natacha Santos, Claúdia Chaves Loureiro, Ana Arrobas, Maria Luís Marques, Carlos Lozoya, Cristina Lopes, Francisca Cardia, Carla Chaves Loureiro, Raquel Câmara, Inês Vieira, Sofia da Silva, Eurico Silva, Natalina Rodrigues, João A. Fonseca. "Profiling Persistent Asthma Phenotypes in Adolescents: A Longitudinal Diagnostic Evaluation from the INSPIRERS Studies." International Journal of Environmental Research and Public Health 18.3 (2021) 1015