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Human epididymis protein 4 (HE4) is a secretory protein encoded by the whey-acidic four-disulfide core domain protein 2 (WFDC2) gene. Clinically, HE4 is an important serological biomarker used to detect and monitor epithelial ovarian cancer. Although elevated in a high percentage of patients with ovarian and endometrial cancer, high serum HE4 levels may also be detected in patients with other various non-gynecologic malignant disorders such as lung adenocarcinoma and breast cancer. However, thedoi:10.5812/hepatmon.101016 fatcat:wcuoj6tjnnfejfi36jxvdwo3ki