SERUM HOMOCYSTEINE AS A RISK FACTOR IN ISCHAEMIC STROKE- A CROSS-SECTIONAL OBSERVATIONAL STUDY IN A TERTIARY CARE TEACHING HOSPITAL IN NORTHERN KERALA
English

Smitha Kalarikkal Satheesan, Shibu Thadathil Sreedharan, Parvathi Krishna Warrier
2017 Journal of Evidence Based Medicine and Healthcare  
BACKGROUND Stroke is a clinically-defined syndrome of rapidly developing symptoms or signs of focal loss of cerebral function with no apparent cause other than that of vascular origin. A previously unrecognised risk factor for stroke, which is prevalent and modifiable and may be causal, is elevated plasma homocysteine. To establish a correlation whether homocysteinaemia has any effect on incidence of young with stroke on our wards, we decided to undertake a cross-sectional observational study
more » ... servational study of patients admitted in the medical wards with first ever-ischaemic stroke. RESULTS Serum homocysteine showed significant increase in patients than in the normal individuals. Mean fasting plasma homocysteine also showed statistically significant difference in both groups. Statistically significant positive correlation was present between plasma Homocysteine and MCV values collected from the subjects. CONCLUSIONS Our study supports that elevated levels of homocysteine might be an independent and modifiable risk factor for stroke in young in our country. Young patients presenting with ischaemic stroke need to be investigated for homocysteine level and treatment modalities to reduce homocysteine levels may help in preventing recurrence of ischaemic stroke.
doi:10.18410/jebmh/2017/32 fatcat:qf2gj6y27nexbe3ipcwf2roeam