Photoacoustic Tomography: Deep Tissue Imaging by Ultrasonically Beating Optical Diffusion [chapter]

Lihong V. Wang
2019 Make Life Visible  
Photoacoustic tomography has been developed for in vivo functional, metabolic, molecular, and histologic imaging by physically combining optical and ultrasonic waves. Broad applications include early-cancer detection and brain imaging. Highresolution optical imaging-such as confocal microscopy, two-photon microscopy, and optical coherence tomography-is limited to superficial imaging within the optical diffusion limit (~1 mm in the skin) of the surface of scattering tissue. By synergistically
more » ... bining light and sound, photoacoustic tomography provides deep penetration at high ultrasonic resolution and high optical contrast. Electronic Supplementary Material The online version of this chapter (https://doi. org/10.1007/978-981-13-7908-6_1) contains supplementary material, which is available to authorized users.
doi:10.1007/978-981-13-7908-6_1 fatcat:dfnsunq4ebbxfdd3gkflljaqai