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Mono- and multi-nucleated ventricular cardiomyocytes constitute a transcriptionally homogenous cell population
2019
Basic Research in Cardiology
Individual adult ventricular cardiomyocytes are either mono- or multi-nucleated and undergo morphological changes during cardiac hypertrophy. However, corresponding transcriptional signatures, reflecting potentially different functions or the ability for cell-cycle entry, are not known. The aim of this study was to determine the transcriptional profile of mono- and multi-nucleated adult cardiomyocytes by single-cell RNA-sequencing (scRNA-seq) and to investigate heterogeneity among
doi:10.1007/s00395-019-0744-z
pmid:31399804
pmcid:PMC6689038
fatcat:azjxlkuqsfdifbjp3fhq2rwcvi