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Objective: To design and validate the content and format of a guidebook for chronic renal failure patients about the care with venous access for hemodialysis at home. Method: Methodological study, in which the steps for the guidebook design were: project planning, literature search, material content, and qualification selection. Results: After analysis of the articles, the content to be included in the guidebook was selected. The first draft of the guidebook was submitted for content and formatdoi:10.1590/0034-7167-2018-0131 pmid:31432944 fatcat:v3h5vk36qbhezc7cjmd6p2sh3m