Three New Sesquiterpenoids and One New Sesquiterpenoid Derivative from Chinese Eaglewood

Huan Zhao, Qinghua Peng, Zhuzhen Han, Li Yang, Zhengtao Wang
2016 Molecules  
Three new sesquiterpenoids (1-3) and one new sesquiterpenoid derivative (4), along with three known sesquiterpenoids (5-7), were isolated from the 95% ethanolic extract of Chinese eaglewood [Aquilaria sinensis (Lour.) Gilg]. The structures of these compounds were elucidated through extensive analysis of spectroscopic data including IR, NMR, HRESIMS, and X-ray diffraction experiments. In addition, the above new compounds were detected for their bioactivities against LPS-induced NO production in
more » ... d NO production in RAW 264.7 cells. Among them, compound 2 exhibited obvious anti-inflammatory activity with an IC 50 value of 8.1 µM.
doi:10.3390/molecules21030281 pmid:26927050 fatcat:zs3t5nz2pbcw3kjuvnfknh4bmq