The aminoacyl-tRNA synthetases of Drosophila melanogaster

Jiongming Lu, Steven J Marygold, Walid H Gharib, Beat Suter
2015 Fly  
Aminoacyl-tRNA synthetases (aaRSs) ligate amino acids to their cognate tRNAs, allowing them to decode the triplet code during translation. Through different mechanisms aaRSs also perform several non-canonical functions in transcription, translation, apoptosis, angiogenesis and inflammation. Drosophila has become a preferred system to model human diseases caused by mutations in aaRS genes, to dissect effects of reduced translation or non-canonical activities, and to study aminoacylation and
more » ... lational fidelity. However, the lack of a systematic annotation of this gene family has hampered such studies. Here, we report the identification of the entire set of aaRS genes in the fly genome and we predict their roles based on experimental evidence and/or orthology. Further, we propose a new, systematic and logical nomenclature for aaRSs. We also review the research conducted on Drosophila aaRSs to date. Together, our work provides the foundation for further research in the fly aaRS field.
doi:10.1080/19336934.2015.1101196 pmid:26761199 pmcid:PMC4826098 fatcat:n2iafrdqofbq7mwewpc6tpsgye