Prognostic value and clinical laboratory assessment of connective tissue exchange disorders in the course of children's traumatic brain injury

Viktoriia Petrenko
2020 Ukrains'kyi Visnyk Psykhonevrolohii  
The author of this paper has carried out clinical laboratory assessment of connective tissue disorders with the purpose of the prognostic value of the course of closed craniocerebral injury of children with different severity. 115 children with closed craniocerebral injury with different severity in the age from 3 to 17 were examined. There were 90 boys and 25 girls among them. The average age of children was (13.5 ± 4.5) years. The distribution of children into groups was carried out according
more » ... rried out according to the clinical forms of traumatic brain injury. The author has accomplished analysis of certain phenotypological signs among patients of clinical groups. The analysis has demonstrated that the most significant phenotypic markers of patients were: postural disorder (anterior curvature / lateral curvature), hypermobility of the joints, platypodia and myopia. Biochemical research methods were used to assess the condition of the connective tissue. The content of connective tissue markers has been analyzed (glucosaminoglycans in the blood serum and daily excretion of oxyproline in the urine). The author has studied biochemical changes on the basis of a comparative analysis of undifferentiated connective tissue disease (UCTD) phenotypic mar kers among the patients of the clinical groups, which demonstrate that the patients had a decrease of general glucosaminoglycans in the blood serum in the presence of UCTD markers, and their redistribution towards a decrease or increase in the I fraction against the background of a significant decrease in the III fraction and an increase in the uronic acids excretion. An increase in oxyproline was observed due to an increase in collagen catabolism. The changes in the metabolism of proteoglycans and collagen, established during the analysis of the results of biochemical studies, indicate instability and insufficiency of connective tissue structures of the patients' body with various signs of dysplasia. Key words: children, traumatic brain injury, connective tissue, phenotypic marker, glucosaminoglycans, oxyproline
doi:10.36927/20790325-v28-is1-2020-7 fatcat:2k4bmprqxbakvmls743tg6rr44