Irritant Contact Dermatitis: Mechanisms to Repair

Cheryl Lee Eberting
2014 Journal of Clinical & Experimental Dermatology Research  
Irritant contact dermatitis is an extremely common condition resulting from epidermal exposure to any number of skin irritants. Upon contact with skin irritants, the epidermis develops many identifiable problems including specific epidermal lipid deficiencies, elevated epidermal pH with concomitant suppression of epidermal lipid production, pHdependent susceptibility to infection, inflammation, and aberrant calcium gradients. By addressing these problems simultaneously, and through irritant
more » ... hrough irritant avoidance, the treatment of irritant contact dermatitis can be maximized. 9554 JCEDR an open access journal Volume 5 • Issue 6 • 1000246 16. Fartasch M, Schnetz E, Diepgen TL (1998) Characterization of detergentinduced barrier alterations --effect of barrier cream on irritation. J Investig Dermatol Symp Proc 3: 121-127.
doi:10.4172/2155-9554.1000246 fatcat:nggfys6jlndrfjsyzxknvjl3gq