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A robust SNP barcode for typing Mycobacterium tuberculosis complex strains
2014
Nature Communications
Strain-specific genomic diversity in the Mycobacterium tuberculosis complex (MTBC) is an important factor in pathogenesis that may affect virulence, transmissibility, host response and emergence of drug resistance. Several systems have been proposed to classify MTBC strains into distinct lineages and families. Here, we investigate single-nucleotide polymorphisms (SNPs) as robust (stable) markers of genetic variation for phylogenetic analysis. We identify B92k SNP across a global collection of
doi:10.1038/ncomms5812
pmid:25176035
pmcid:PMC4166679
fatcat:m4eqgignjrbv7ngv7c4gmwwora