Behavioral and Sleep Disorders in Neurofibromatosis

J Gordon Millichap
2005 Pediatric Neurology Briefs  
COMMENT. The authors list three novel findings: 1) the quantifiable delay in early development of infants with sagittal synostosis (SS) demonstrated in a controlled, prospective, longitudinal study; 2) a preoperative delay in gross locomotor development; and 3) a significant postoperative resolution of locomotor deficits. Previous studies have reported developmental delay only in older patients and without normal controls and prospective follow-up; mental rather than motor development has been
more » ... velopment has been considered; and delayed gross locomotor development with improvement after surgery has not previously been demonstrated in young infants. One study is cited that supports the present findings but in young children: 35.5% of 50 children with SS had cerebral palsy, psychomotor retardation, and/or neurological signs, and many of the deficits resolved after surgery, only 14.5% having persistent abnormal signs (Kaiser G. Childs Nerv Syst 1988;4:223-230). Raised intracranial pressure was considered an unlikely factor in the mechanism of improved locomotor function following surgery in the Leeds series.
doi:10.15844/pedneurbriefs-19-4-4 fatcat:emx6zbkyzvcwtknmj4hsdrngey