The Gut is not only the Target but a Source of Inflammatory Mediators Inhibiting Gastrointestinal Motility During Sepsis

Ingmar Königsrainer, Michael H. Türck, Friederike Eisner, Tobias Meile, Jonas Hoffmann, Markus Küper, Derek Zieker, Jörg Glatzle
2011 Cellular Physiology and Biochemistry  
Sepsis is a common problem in intensive care patients leading to multi-organ failure and gastrointestinal paralysis. Aim: The aim of the study was to investigate whether the gastrointestinal tract is not only the target but also the source of inflammatory mediators inhibiting gastrointestinal motility. Methods: Mesenteric lymph was obtained from rats in which a sepsis was induced by lipopolysaccharide (LPS) intraperitoneally. Gastrointestinal motility was recorded following mesenteric lymph-or
more » ... NFα infusion into the jugular vein of separate healthy recipient rats using the strain gauge transducer technique. Results: Infusion of sepsis lymph significantly impairs gastric and colonic motility, decreasing the motility-index in the stomach and colon by about 57% and 21% respectively in comparison to baseline motility. Among other inflammatory mediators, TNFα plays an important role in mediating the inhibitory effect of mesenteric lymph on gastrointestinal motility during sepsis. Conclusions: The gastrointestinal tract is the source and the target of inflammatory mediators released during sepsis causing paralytic ileus.
doi:10.1159/000335769 pmid:22178887 fatcat:zlpa43izn5bkvp37zi7mu6ayq4