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Disseminated infections due to Candida albicans are frequently encountered in immunocompromised patients. We compared the antifungal activities of macrophages residing in spleen, liver and lungs of rabbits against blastoconidia and pseudohyphae of C. albicans. Splenic adherent cells (SAC), Kupffer cells (KC) and pulmonary alveolar macrophages (PAM) all ingested blastoconidia ef ciently. SAC caused signi cantly more damage to unopsonized pseudohyphae compared with KC (P B 0·01) or PAM (P Bdoi:10.1080/mmy.18.104.22.168 pmid:11204141 fatcat:dwe7xr7bqffq5p5wi3krjogiem