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Levels of a wide range of biogenic amines and related metabolites were determined in the brain of the silk worm, Bomby mori, during pupal and adult development using a three-dimensional HPLC system with multiple coulometric electrochemical detection. In the brain of the female adults, metabolic pathways such as tyrosine (TYR-4)->dihydroxyphenylalanine (L -DOPA)-dopamine (DA), TYR-4->tyramine (TYRA), and tryptophan (TRP)->5-hydroxytryptamine (5-HT) were identified. At this stage,doi:10.1515/znc-1997-3-424 fatcat:xe7fvpzm7jcppboqhbwegev35y