Higher inflammation and cerebral white matter injury associated cognitive deficit in asthmatic patients with depression [post]

Yan Shang, Bi Xiaoying, Yue Lu, Shu Zhou, Cunxiu Fan
2020 unpublished
Background Depression is a common co-morbidity in asthma, worsening asthma control and impairing patient's quality of life. Previous studies have reported a higher risk of cognitive deficit in depression. However, few research has focused on the cognitive status of asthmatic patients with depression. Evidence showed that inflammation may play an important role in both asthma and depression. Moreover, cerebral white matter injury, which could be induced by inflammation, has been associated with
more » ... en associated with depression. The present study aimed to assess the cognitive function and explore the potential mechanism in patients with asthma, depression and comorbidity. Methods We admitted four groups: Asthma comorbid Depression group (A + D, n = 26), Depression group (D, n = 25), Asthma group (A, n = 33) and Normal controls (N, n = 28). Cognitive function was assessed by Montreal Cognitive Assessment (MoCA). Various inflammatory cytokines were measured, including interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), high-mobility group box 1(HMGB1) and Netrin-1. Cerebral white matter injury was assessed by serum myelin basic protein (MBP) and myelin oligodendrocyte glycoprotein (MOG), and their correlations with cognitive performance were calculated. Results A + D group showed the highest incidence of cognitive deficit with specific affected cognitive domain. Compared to N group, serum levels of IL-6, HMGB1, Netrin-1, MBP and MOG were significantly elevated in A + D group. MOG level was negatively correlated with MoCA score. Conclusion Patients with comorbid condition presented more definite, severe cognitive deficit and higher level of inflammatory cytokines. Cerebral white matter injury may account for the cognitive deficit in these patients and MOG could be a potential biomarker of this process.
doi:10.21203/rs.3.rs-23307/v1 fatcat:ihvenkepnba2xh3ty76kiihqdm