Glutathione status in the blood of rats after reticulocytosis induced by phenylhydrazine and bleeding

Snezana Markovic, Ana Obradovic, Jovana Zizic, Branka Ognjanovic, A.S. Stajn, Zorica Saicic, M.B. Spasic
2010 Archives of Biological Sciences  
In this experiment, we compared the in vivo effects of phenylhydrazine (PHZ) and bleeding treatment on the redox status and glutathione antioxidative mechanism parameters in the plasma and red blood cells (RBC) of rats. Results showed a lower level of reactive oxygen species (ROS), a higher level of lipid peroxidation and the effective antioxidative role of the glutathione system in the blood of bleeding rats. PHZ-treatment induced higher concentrations of ROS and an accumulation of oxidized
more » ... tion of oxidized glutathione in the plasma, while the glutathione system showed a satisfactory antioxidative capacity in the RBC of rats. When comparing the two anemic groups, the PHZ-treated rats showed marked oxidative stress in the plasma.
doi:10.2298/abs1003589m fatcat:2bxiodazwba67arxdgua4jsnzm