Healthcare-associated infection is one of the most common complications of health care management. Aim of study: Train the trainer nurses on infection control at student Hospital Mansura University. Research Design: Quasi research design was used to conduct this study. Data collection: the data was collected during the period of August to October 2015 from nurses. Setting: The study was conducted at Students Hospital affiliated to Mansoura University (emergency ward, clinics, inpatient ward,

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... rating room and private ward). Study sample: convenient sample was used it consists of (70 nurses include 10head nurses, 60 staff nurses).Tools: five tools were used in this study: tool I:Self administrated questionnaire to assess socio demographic and professional characteristics. Tool II: Self administrated questionnaire to assess nurses' knowledge about infection control. Tool III: self-administrated questionnaire to assess nurses' subjective performance. Tool IV: An observation check list to assess nurses' performance Tool V: Nurses' acceptance and satisfaction scale. Results: reveals that the mean scores of nurse's knowledge before implementing the program was 15.22(7.25)while after program implementation the mean score improved to40.12(4.31). There was statistically significant difference between total mean score of nurses' knowledge pre and post training program p=0.00. Regarding subjective performance the mean scores of nurse's before program the implementing was 1.66 ± 1.39while after program implementation improved to 6.56 ± .77. There was statistically significant difference between mean score of nurses' subjective performance pre and post training program p=0.00. Conclusion: This study concluded that nurses' knowledge and performance were poor in pre-program and improved in post program.