α-Glucosidase Inhibitory Constituents from Acanthopanax senticosus Harm Leaves

Zhi-Bin Wang, Hai Jiang, Yong-Gang Xia, Bing-You Yang, Hai-Xue Kuang
2012 Molecules  
A new triterpene glycoside, 3-O-[(α-L-rhamnopyranosyl)(1→2)]-[β-Dglucuronopyranosyl-6-O-methyl ester]-olean-12-ene-28-olic acid (1) and a new indole alkaloid, 5-methoxy-2-oxoindolin-3-acetic acid methyl ester (5) were isolated from the leaves of Acanthopanax senticosus Harms along with six known compounds. The structures of the new compounds were determined by means of 2D-NMR experiments and chemical methods. All the isolated compounds were evaluated for their glycosidase inhibition activities
more » ... ibition activities and compound 6 showed significant α-glucosidase inhibition activity.
doi:10.3390/molecules17066269 pmid:22634838 fatcat:q3wa5rjvmbgnvh2mkiql4mulym