Association of apoprotein A-1 genetic variants with atherosclerosis development in Saint-Petersburg

Valentina V Miroshnikova, Tatyana I Rodygina, Ekaterina P Demina, Pavel S Kuryanov, Soreya A Urazgildeeva, Victor S Gurevich, Alexander L Schwarzman
2010 Экологическая генетика  
Apoprotein A-1 is a major protein in antiaterogenic high density lipoproteins and it is one of key proteins regulating reverse cholesterol transport. In this study we have investigated association of APOA1 gene polymorphism with atherosclerosis development among Saint-Petersburg population. Allelic frequencies of polimorphic variants (-75)G/A and 83C/T of APOA1 gene were determined in the group of patients with angiographically proven aterosclerosis and in control group. Allele 83T of the APOA1
more » ... le 83T of the APOA1 gene is associated with lower risk of atherosclerosis development among Saint-Petersburg population.
doi:10.17816/ecogen8224-28 fatcat:to7czfl74vbaxcuctkeqwlc6ji