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Increased expression of CYP1A1 and CYP1B1 in ovarian/peritoneal endometriotic lesions
2016
Reproduction
Endometriosis is an estrogen-dependent disease affecting up to 10% of all premenopausal women. There is evidence that different endometriosis sites show distinct local estrogen concentration, which, in turn, might be due to a unique local estrogen metabolism. We aimed to investigate whether there was a site-specific regulation of selected enzymes responsible for the oxidative metabolism of estrogens in biopsy samples and endometrial and endometriotic stromal cells. Cytochrome P450 (CYP) 1A1 and
doi:10.1530/rep-15-0581
pmid:27012269
fatcat:diw5ijuhanf7vlq3ntgo4ku2gq