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This article investigates two cases of priority setting to explore how, in addition to technical considerations, ethical and political factors shape the allocation of health resources. First, we discuss how Thai authorities adjudicated a coverage decision for HLA-B*1502 screening, which meets the national cost-effectiveness threshold for only some of the conditions it can detect. Second, we consider England's Cancer Drugs Fund to investigate the interplay of technical decision making anddoi:10.1080/23288604.2016.1124169 fatcat:cpjum45prnglbmrcyunap3izum