Butorphanol Mitigates Emergence Agitation in Patients Undergoing Functional Endoscopic Sinus Surgery: A Randomised Controlled Clinical Trail [post]

Siyi Qi, Wanbing Dai, Weitian Tian, Yizhe Zhang, Li Zheng, Weifeng Yu, Jie Tian, Diansan Su, Xiaorong Huai
2020 unpublished
Background: This study explored the effectiveness of preoperative intravenous injection of butorphanol in the alleviation of emergence agitation (EA) in patients undergoing functional endoscopic sinus surgery (FESS).Methods: Patients (n = 708) were randomized into two groups. The butorphanol group (Group B, n=358) received butorphanol infusion (20 ug/kg) before anaesthesia induction, while the control group (Group C, n=350) received an equal volume of normal saline infusion. General anaesthesia
more » ... General anaesthesia was induced with sufentanil, propofol and rocuronium, and was maintained with sevoflurane and remifentanil. Vasoactive drugs maintained the haemodynamic indices within 20% of the baseline.Results: The incidence of EA (Group B vs. C: 24.3 vs. 31.4%, P = 0.034). The times to spontaneous breathing (26.5 min vs. 23.7 min, P = 0.011), verbal response (36.0 min vs. 33.4 min, P = 0.012) and extubation (31.0 min vs. 28.7 min, P = 0.025) were longer in Group B, and the grade of cough (0.33 vs. 0.43, P = 0.024) at extubation in Group B was lower than that in Group C (P = 0.024). The mean arterial pressure at the end of the operation (P = 0.004) and at 5 min after extubation (P = 0.008) was higher and hypotension was less prominent (0.6% vs. 2.6%, P = 0.030) in Group B.Conclusions: Preoperative intravenous injection of butorphanol decreased the incidence of EA after FESS, and provided smooth and haemodynamically stable emergence without extending the stay in post-anaesthesia care unit.Trial registration: Clinicaltrials.gov, NCT03398759. Registered 21 December 2017, https://www.clinicaltrials.gov/ct2/show/NCT03398759?term=03398759&draw=2&rank=1
doi:10.21203/rs.3.rs-78029/v1 fatcat:2m7k34xuinexflcevm5kvw3rby