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bZIP) DNA-binding proteins play key roles in regulating gene transcription. Their DNA binding domains consist of the basic region juxtaposed to a heptad repeats of leucines. bZIP proteins from the same family recognize a unique palindromic DNA motif. bZIP peptide binds to DNA as a dimer of α helices. Dimerization is mediated by the leucine zipper; each basic region contacts a half-site in the major groove of the DNA. We solved the crystal structure of the C/EBPα bZIP peptide bound to a 21-merdoi:10.2210/pdb1ue5/pdb fatcat:ey6uohbhingw3lg3eztczxy2e4