Neuronal-type alpha-bungarotoxin receptors and the alpha 5-nicotinic receptor subunit gene are expressed in neuronal and nonneuronal human cell lines

B. Chini, F. Clementi, N. Hukovic, E. Sher
1992 Proceedings of the National Academy of Sciences of the United States of America  
a-Bungarotoxin (aBgtx) is a toxin known to interact with muscle nicotinic receptors and with some neuronal nicotinic receptors. We show that aBgtx binding sites are also expressed in nonmuscle and nonneuronal human cells, including small cell lung carcinoma and several epithelial cell lines. These receptors are immunologically related to the aBgtx receptors of unknown function described in the nervous system and in the IMR32 neuroblastoma cell line and are distinct from muscle nicotinic receptors. We have also cloned from IMR32
doi:10.1073/pnas.89.5.1572 pmid:1542648 pmcid:PMC48494 fatcat:sselaaze7ncrdpx3ryd26eefeq