Aerobic exercise and not a diet supplemented with jussara açaí (Euterpe edulis Martius) alters hepatic oxidative and inflammatory biomarkers in ApoE-deficient mice

Cynthia Aparecida de Castro; Antonio José Natali; Luciana Marques Cardoso; Alessandra Barbosa Ferreira-Machado; Alexandre Azevedo Novello; Karina Ana da Silva; Natalia Filard Tafuri; Sergio Luis Pinto da Matta; Maria Lucia Pedrosa; Maria do Carmo Gouveia Peluzio

doi:10.1017/s000711451400083x

The pulp of jussara açaí (Euterpe edulisMartius) fruit is rich in anthocyanins that exert antioxidant and anti-inflammatory effects similar to those exerted by aerobic exercise. In the present study, we investigated the effects of jussara açaí fruit pulp consumption, either alone or in combination with aerobic exercise, on the hepatic oxidative and inflammatory status of ApoE-deficient (ApoE− / −) mice. Male mice were divided into four groups (control (C), control plus açaí, exercise plus açaí

more »

... EXA) and exercise (EX)) and fed the AIN-93M diet or the AIN-93M diet formulated to contain 2 % freeze-dried açaí pulp. Mice in the EX and EXA groups were subjected to a progressive running programme (5 d/week, 60 min/d, 16 m/min) for 12 weeks. Mice that were made to exercise exhibited reduced (40·85 %;P< 0·05) hepatic superoxide dismutase activity when compared with the C mice, independent of the açaí diet. Mice in the EX group exhibited a lower (42 %;P< 0·05) mRNA expression of monocyte chemotactic protein-1 in the liver compared with the C mice. Mice in the EXA and EX groups had lower percentages of hepatic lipid droplets (70 % and 56 %, respectively;P< 0·05) when compared with the C mice. Mice in the EX group had smaller (58 %;P< 0·05) area of lesions in the aorta when compared with the C mice. Serum lipid profile was not affected (P>0·05). In conclusion, aerobic exercise training rather than açaí fruit pulp consumption or a combination of both enhances the hepatic oxidative and inflammatory status ofApoE− / −mice.

doi:10.1017/s000711451400083x pmid:24787366 fatcat:gda2yaiejnh75ciq7kjcxr2bgy

Citation

Cynthia Aparecida de Castro, Antonio José Natali, Luciana Marques Cardoso, Alessandra Barbosa Ferreira-Machado, Alexandre Azevedo Novello, Karina Ana da Silva, Natalia Filard Tafuri, Sergio Luis Pinto da Matta, Maria Lucia Pedrosa, Maria do Carmo Gouveia Peluzio. "Aerobic exercise and not a diet supplemented with jussara açaí (Euterpe edulis Martius) alters hepatic oxidative and inflammatory biomarkers in ApoE-deficient mice." British Journal of Nutrition 112.03 (2014) 285-294

Aerobic exercise and not a diet supplemented with jussara açaí (Euterpe edulis Martius) alters hepatic oxidative and inflammatory biomarkers in ApoE-deficient mice

Preserved Fulltext