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Mammalian Sterile 20–Like Kinases in Tumor Suppression: An Emerging Pathway: Figure 1
2005
Cancer Research
Preserved Fulltext
Emerging evidence suggests that the proapoptotic kinase mammalian sterile 20-like kinase 2 (MST2) acts in a novel tumor suppression pathway. Recently, we showed that Raf-1 kinase sequesters and inhibits MST2 and that this event is critical for Raf-mediated cell survival. In this review, we summarize Raf control of MST2 and we outline a novel pathway involving the downstream effector proteins Salvador and Warts/Lats that may act to limit the positive effects of Raf-mitogen-activated protein
doi:10.1158/0008-5472.can-05-1453
pmid:15994916
fatcat:4sw43i4cbrcmpmygjbfjpdks3m