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Proto-oncogene c-erbB-2 is located in chromosome 17 region q21 and codifies a 185 Kd protein, with tyrosine kinase activity. The amplification of this gene is associated with relapse and lower survival in breast cancer. Overexpression of this gene can be detected by immunohistochemistry (IHC). However, fluorescence in situ hybridization (FISH) and chromogenic in situ hybridization (CISH) allow the simultaneous analysis of morphology and overexpression of the gene. Aim: To evaluate thedoi:10.4067/s0034-98872005000200001 pmid:15824823 fatcat:nnvg4z23trbfhe2r5vr3imt3ey