2,7-Diazabicyclo[2.2.1]heptanes: Novel Asymmetric Access and Controlled Bridge-Opening

N. S. Simpkins, Gary R Peczkowski, Philip Craven, Darren Stead
2019 Chemical Communications  
Organocatalysed asymmetric Michael additions of substituted triketopiperazines to enones afford products in high yield and enantiomeric ratio (er). Further modification delivers products possessing natural product (NP) scaffolds including diazabicyclo[2.2.1]heptane, prolinamide...
doi:10.1039/c8cc10263e fatcat:jjiakz4larggnmm46iilc4s574