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Increasing studies have suggested that rapamycin has inhibitory effect for cancer cell proliferation. The present study aimed to investigate the effect of rapamycin on the proliferation of A549 lung cancer cells and try to elucidate its probable mechanism. A549 cells were randomly divided into the following 3 groups (n=6): the Dulbecco's modified Eagle's medium (DMEM) culture solution administered alone group (C group), the 10 nmol/l rapamycin administered alone group (R group) and the 5 mmol/lpmid:24706303 fatcat:yjiabfliirccddgvrwejljfjaq