Damage of DNA and Its Recovery in AH-109A Cells Treated with Carboquone in Vivo

RYUNOSUKE KANAMARU, MITSUO ASAMURA, YOSHITO HAYASHI, HARUHIKO SATO, TATUO SAITO
1978 Tohoku journal of experimental medicine  
of DNA and Its Recovery in AH-109A Cells Treated with Carboquone in Vivo . Tohoku J. exp. Med., 1978, 124 (4), 331-337 -A single injection of carbo quone at a dose of 0.1 mg/kg body weight induced damage of DNA of AH-109A cells as revealed by alkaline and neutral sucrose density gradient centrifugation . A significant decrease in the sedimentation velocity of DNA on alkaline sucrose density gradient centrifugation was observed 15 min after the injection, and it returned to that of control after
more » ... at of control after 60 min. Thereafter, the size of DNA decreased
doi:10.1620/tjem.124.331 fatcat:6ad3zr3h4bcsve45fu6ox63cwm