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A series of some new 1-thiocarbamoyl-3-(2,5-dimethylfuran-3-yl)-5-(fluoro/trifluoromethylphenyl) -2-pyrazolines 4a-f have been synthesized by treating with various fluoro/trifluoromethyl substituted chalcones, thiosemicarbazide and potassium carbonate using conventional heating and solventfree microwave irradiation techniques. The easy work-up of the products, rapid reaction and mild conditions are noticeable features of this protocol. Synthesized compounds have been screened for their in vitrodoi:10.13005/ojc/320232 fatcat:czu5c4jpxzbcneebgi3lodymy4