Microwave Solvent-free Synthesis of Some Bioactive 3-(2,5-Dimethylfuran-3-yl)-pyrazoline Derivatives and their Antimicrobial Activity

S Kulathooran, T Vadivel, M Dhamodaran, B Selvakumar
2015 Oriental Journal of Chemistry  
A series of some new 1-thiocarbamoyl-3-(2,5-dimethylfuran-3-yl)-5-(fluoro/trifluoromethylphenyl) -2-pyrazolines 4a-f have been synthesized by treating with various fluoro/trifluoromethyl substituted chalcones, thiosemicarbazide and potassium carbonate using conventional heating and solventfree microwave irradiation techniques. The easy work-up of the products, rapid reaction and mild conditions are noticeable features of this protocol. Synthesized compounds have been screened for their in vitro
more » ... for their in vitro antimicrobial activity against six microbial strains. Among them, 1-Thiocarbamoyl-3-(2,5-dimethylfuran-3-yl)-5-(3-fluorophenyl)-2-pyrazoline 4b showed maximum zone of inhibition against all the tested microorganisms. Structural elucidation of the synthesized compounds were determined on the basis of various spectroscopic methods.
doi:10.13005/ojc/320232 fatcat:czu5c4jpxzbcneebgi3lodymy4