The burden of gestational diabetes mellitus in Jamaican women with a family history of autosomal dominant type 2 diabetes

Rachael R. Irving, James L. Mills, Eric G. Choo-Kang, Errol Y. Morrison, Santosh Kulkarni, Rosemarie Wright-Pascoe, Wayne Mclaughlin
2008 Revista Panamericana de Salud Pública  
Objectives. To determine if Jamaican women of African descent with a family history of early onset autosomal dominant type 2 diabetes have greater odds of developing gestational diabetes mellitus (GDM) than those without a family history of the disease. Methods. A comparative study was conducted of two groups of pregnant Jamaican women: the first with a family history of early onset autosomal dominant type 2 diabetes; the second with no history of the disease. Incidence, odds for developing
more » ... for developing GDM, and metabolic profiles in first and second trimesters were assessed using SPSS 11.5 (SPSS Inc., Chicago, Illinois, United States). Results. The incidence of GDM was 12.0 % in women with a family history of early onset autosomal dominant type 2 diabetes and 1.5% in women without a family history of the disease (P < 0.05). Women with a family history were nine times more likely to develop GDM than those without a family history of diabetes (95% confidence interval: 5.00-16.38, P < 0.0001). Conclusion. Family history of early onset autosomal dominant type 2 diabetes appears to increase susceptibility to GDM in Jamaican women. Pregnant women of any age with family history of early onset autosomal type 2 diabetes should be screened for GDM.
doi:10.1590/s1020-49892008000200003 pmid:18371278 fatcat:oi35rsuusnc7plovtphpph2iju