We report a case of migration of intravitreal perfluorocarbon into cranial space and further removed through a lumbar puncture treatment. The patient showed a sudden onset of hypoxemia and hypotension during an ocular surgery, which was highly suspected as neurogenic pulmonary edema caused by the migrated perfluorocarbon. The patient's symptoms improved after extracorporeal membrane oxygenation (ECMO). The perfluorocarbon gradually descended through subarachnoid space to lumbar cisterna and

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... lly drained by a lumbar puncture. The patient was successfully saved but left vision loss. Perfluorocarbon could enter the cranial space during ocular surgery and threaten the life of patients. Further migrating through subarachnoid space provides the opportunity to remove it.