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The cells continuously secrete a large number of different types of microvesicles including macro-and micro-molecules into the extracellular fluids. One of them are exosomes, which are nano-sized vesicles capable of transferring the DNAs, microRNAs, non-coding RNAs and lipids with or without direct cell to cell contact, so representing the novel way of intracellular communication. In this review, we tried to summarize the exosomal structure, composition, formation, and isolation. We alsopmid:25272880 fatcat:zkrrwkzdvvaozlh5kuwzr5wwp4