Dyscirculatory Angiopathy of Alzheimer's Type

Ivan V. Maksimovich
2011 Journal of Behavioral and Brain Science  
Purpose: We assess the significance of dyscirculatory angiopathy of Alzheimer's type (DAAT) in identifying the predisposition to the development and diagnosis of Alzheimer's disease (AD) different stages. Methods: 108 patients took part in the research:1) 49 aged 34-79 suffering from AD or running an increased risk of its development (those not diagnosed with AD but having growing memory disorders without any manifestations of dementia or specific cognitive impairments, and having 2 or more
more » ... aving 2 or more immediate relatives with AD) -Test Group; 2) 59 aged 28-78 suffering from different types of brain lesions accompanied by dementia but not suffering from AD or corresponding to their age norm -Control Group. All the patients underwent MRI, CT with subsequent calculation of the temporal lobes atrophy degree, brain scintigraphy (SG), rheoencephalography (REG), and MUGA. Results: Characteristic features of patients with an increased risk of AD as well as at its various stages are: 1) Temporal lobes and hippocampus atrophy ranging from 4% among those with an increased risk of AD to 62% among those at its advanced stages; 2) DAAT manifestations: reduction of the capillary bed in the temporal and frontoparietal regions with the development of multiple arteriovenous shunts of the same localization and correspondent early venous discharge accompanied by venous stasis on the border of the frontal and parietal region; 3) DAAT phenomena equally develop both among those with an increased risk of developing AD and those at various AD stages. Similar changes are not observed among Control Group patients with other brain lesions, regardless of the severity of dementia, as well as among practically healthy people of the corresponding age group. Conclusion: Timely identification of the abovementioned changes can reveal a predisposition to AD development long before its initial manifestations, and it allows differentiating AD from other diseases attended by dementia. In both cases, timely diagnosis allows beginning timely treatment and thus achieving more stable results.
doi:10.4236/jbbs.2011.12008 fatcat:ozuzi2bo5rbkpjk3fhpcbjz5je